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Cockcroft-Gault Equation:
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The Cockcroft-Gault equation estimates creatinine clearance (CrCl) from serum creatinine, age, weight, and gender. It is widely used for drug dosing adjustments in patients with renal impairment and for assessing kidney function.
The calculator uses the Cockcroft-Gault equation:
Where:
Explanation: The equation estimates the rate at which creatinine is cleared from the blood by the kidneys, providing an approximation of glomerular filtration rate.
Details: Creatinine clearance is essential for drug dosing adjustments, particularly for medications with narrow therapeutic windows that are renally excreted. It helps prevent toxicity in patients with impaired kidney function.
Tips: Enter age in years, weight in kilograms, serum creatinine in mg/dL, and select gender. All values must be valid (age between 1-120, weight > 0, creatinine > 0).
Q1: What is the difference between CrCl and eGFR?
A: CrCl estimates creatinine clearance while eGFR estimates glomerular filtration rate. CrCl is often used for drug dosing, while eGFR is used for CKD staging.
Q2: What are normal CrCl values?
A: Normal CrCl is approximately 95-125 mL/min for young adults, declining with age. Values below 60 mL/min indicate renal impairment.
Q3: When should ideal body weight be used?
A: For obese patients (BMI > 30), ideal body weight should be used instead of actual body weight for more accurate estimation.
Q4: Are there limitations to this equation?
A: Less accurate in elderly, malnourished, obese patients, and those with unstable renal function or extreme muscle mass.
Q5: Can this be used for pediatric patients?
A: No, the Cockcroft-Gault equation is validated for adults only. Pediatric patients require age-specific equations.